Medication:
AMOXICILLIN (1889K)
Aldomet
methyldopa
Company
Aspen Pharmacare Australia Pty Ltd
MIMS Class:
Antihypertensive agents - Cardiovascular System
Pregnancy Category
A Drugs which have been taken by a large number of pregnant women and women of childbearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the fetus having been observed. See TGA disclaimer and copyright.
Sports Category
Permitted in sport
ARTG Classification:
Registered medicine
Use:
Centrally acting antiadrenergic (α2 agonist). Mild-severe hypertension
Contraindications:
Active hepatic disease (incl cirrhosis, acute hepatitis); methyldopa assoc hepatic disorder history; concomitant MAOIs; catecholamine secreting tumour eg phaeochromocytoma, paraganglioma; porphyria
Precautions:
Anaemia; hepatic dysfunction, disease history; renal impairment; dialysis; monitor LFTs, WCC incl differential (1st 6-12 wks of treatment, unexplained fever), for depression (esp depression history); anaesthesia; angina; elderly; women of childbearing potential; pregnancy, lactation
Adverse Reactions:
Abnormal LFTs, fever, jaundice (disc); sedation; headache; dizziness; asthenia; paraesthesia; +ve ANA, LE cell, rheumatoid factor; lupus-like syndrome; angioedema; rash; TEN; depression; GI upset; pancreatitis; sore, black tongue; pericarditis; A-V block; bradycardia; prolonged carotid sinus hypersensitivity; angina aggravation; orthostatic hypotension; oedema; hyperprolactinaemia; blood dyscrasia; haemolytic anaemia, hepatic necrosis (rare); others, see full PI
Interactions:
See Contra; other antihypertensives; anaesthetics; lithium; Fe sulfate, gluconate; lab tests: uric acid (phosphotungstate method), serum creatinine (alkaline picrate method), AST (colorimetric method); +ve direct Coombs' test; false +ve urinary catecholamines; see full PI
ALDOMET TABLETS RX (S4)
Methyldopa (sesquihydrate); propylene glycol; yellow f-c gluten free
Dose: May be taken with or without food. Adults: initially 250 mg 2-3 times daily for 48 hrs; may adjust dose at ≥ 2 day intervals until adequate response achieved (incr evening dose 1st may be pref); max 3 g/day. Children: initially 10 mg/kg/day in 2-4 divided doses; adjust according to response; max 65 mg/kg/day or 3 g/day (whichever is less). Elderly: decr dose. Renal impairment: may respond to lower doses. Following previous antihypertensives: initially ≤ 500 mg/day; may require dose adjustment of other antihypertensives; see full PI
Pack 250 mg [100]
(AUSTR34361)
PBS/RPBS (MP,NP) (Rp 5)
methyldopa
Company
Aspen Pharmacare Australia Pty Ltd
MIMS Class:
Antihypertensive agents - Cardiovascular System
Pregnancy Category
A Drugs which have been taken by a large number of pregnant women and women of childbearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the fetus having been observed. See TGA disclaimer and copyright.
Sports Category
Permitted in sport
ARTG Classification:
Registered medicine
Use:
Centrally acting antiadrenergic (α2 agonist). Mild-severe hypertension
Contraindications:
Active hepatic disease (incl cirrhosis, acute hepatitis); methyldopa assoc hepatic disorder history; concomitant MAOIs; catecholamine secreting tumour eg phaeochromocytoma, paraganglioma; porphyria
Precautions:
Anaemia; hepatic dysfunction, disease history; renal impairment; dialysis; monitor LFTs, WCC incl differential (1st 6-12 wks of treatment, unexplained fever), for depression (esp depression history); anaesthesia; angina; elderly; women of childbearing potential; pregnancy, lactation
Adverse Reactions:
Abnormal LFTs, fever, jaundice (disc); sedation; headache; dizziness; asthenia; paraesthesia; +ve ANA, LE cell, rheumatoid factor; lupus-like syndrome; angioedema; rash; TEN; depression; GI upset; pancreatitis; sore, black tongue; pericarditis; A-V block; bradycardia; prolonged carotid sinus hypersensitivity; angina aggravation; orthostatic hypotension; oedema; hyperprolactinaemia; blood dyscrasia; haemolytic anaemia, hepatic necrosis (rare); others, see full PI
Interactions:
See Contra; other antihypertensives; anaesthetics; lithium; Fe sulfate, gluconate; lab tests: uric acid (phosphotungstate method), serum creatinine (alkaline picrate method), AST (colorimetric method); +ve direct Coombs' test; false +ve urinary catecholamines; see full PI
ALDOMET TABLETS RX (S4)
Methyldopa (sesquihydrate); propylene glycol; yellow f-c gluten free
Dose: May be taken with or without food. Adults: initially 250 mg 2-3 times daily for 48 hrs; may adjust dose at ≥ 2 day intervals until adequate response achieved (incr evening dose 1st may be pref); max 3 g/day. Children: initially 10 mg/kg/day in 2-4 divided doses; adjust according to response; max 65 mg/kg/day or 3 g/day (whichever is less). Elderly: decr dose. Renal impairment: may respond to lower doses. Following previous antihypertensives: initially ≤ 500 mg/day; may require dose adjustment of other antihypertensives; see full PI
Pack 250 mg [100]
(AUSTR34361)
PBS/RPBS (MP,NP) (Rp 5)